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KMID : 0380020120270010057
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Korean Journal of Biotechnology and Bioengineering
2012 Volume.27 No. 1 p.57 ~ p.60
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Evaluation of Anti-diabetic Effect of Biochanin A in C2C12 Myotube
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Hwang Jin-Taek
Kim Sung-Hee
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Abstract
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In this study, we evaluated the effects of Biochanin A on glucose uptake in C2C12 myotube. We found that Biochanin A significantly stimulated 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-d-glucose (2-NBDG) uptake in a dose-dependent manner. In addition, AMPK and PPAR-gamma activities were markedly increased by Biochanin A in a dose-dependent manner. However, Akt, an insulin dependent signaling molecule, did not change by Biochanin A. These results suggest that Biochanin A stimulates glucose uptake via AMPK and PPAR-gamma pathways.
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KEYWORD
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Biochanin A, Anti-diabetes, C2C12 myotube, PPAR-gamma, AMP-activated protein kinase
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